genoSCORE and Polygenic Risk Scoring
Utility of Polygenic Risk Scoring to Predict Cognitive Impairment as Measured by Preclinical Alzheimer Cognitive Composite Score (PACC)
Q. Gao, P. Daunt, A.M. Gibson, R.J. Pither; for the Alzheimer’s Disease Neuroimaging Initiative
J Aging Res & Lifestyle 2022;11:1-8
Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease
P. Daunt, C. G. Ballard, B. Creese, G. Davidson, J. Hardy, O. Oshota, R. J. Pither, A. M. Gibson
J Prev Alzheimers Dis (2020) 10.14283/jpad.2020.64
Stratification of individuals for PET amyloid positivity and Alzheimer’s Disease risk using polygenic risk score analysis – new opportunities for clinical trial design.
Pither R, Leonenko G, Bellou E et al. 
Poster presentation at AAIC 2018
Polygenic score prediction captures nearly all common genetic risk for Alzheimer’s disease.
Escott-Price V, Shoai M, Pither R et al. 
Neurobiology of Aging 2016; 4:214e7-214e11
Common polygenic variation enhances risk prediction for Alzheimer’s disease
Escott-Price V, Sims R, Bannister C et al. 
Brain 2015; 138:3673-3684
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder, A International Schizophrenia Consortium
Purcell SM, Wray NR, Stone JL et al.
Nature 2009; 460:748-52
Lifestyle interventions
Dementia prevention, intervention, and care: 2020
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N
Lancet. 2020 Aug 08;396(10248):413-446. doi: 10.1016/S0140-6736(20)30367-6
Dementia prevention, intervention, and care
Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N.
Lancet. 2017 Dec 16;390(10113):2673-2734. doi: 10.1016/S0140-6736(17)31363-6.
The Effect of an Online Cognitive Training Package in Healthy Older Adults: An Online Randomized Controlled Trial.
Corbett A, Owen A, Hampshire A, Grahn J, Stenton R, Dajani S, Burns A, Howard R, Williams N, Williams G, Ballard C. 
J Am Med Dir Assoc. 2015 Nov 1;16(11):990-7. doi: 10.1016/j.jamda.2015.06.014.
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A,  Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M
Lancet 2015;385:2255–2263
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease
Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP
JAMA. 2008 Sep 3;300(9):1027-37. doi: 10.1001/jama.300.9.1027.
ACTIVE Study Group Long-term effects of cognitive training on everyday functional outcomes in older adults
Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, Morris JN, Rebok GW, Unverzagt FW, Stoddard AM, Wright E;
JAMA. 2006 Dec 20;296(23):2805-14. doi: 10.1001/jama.296.23.2805.
Alzheimer’s disease
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis
L.A. Farrer, L.A. Cupples, J.L. Haines. B. Hyman, W.A. Kukull, R. Mayeux, R.H. Myers, M.A. Pericak-Vance, N. Risch, C.M. van Duijn’ 
APOE and Alzheimer Disease Meta Analysis Consortium JAMA (1997) p1349-56
Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study.
Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, et al. 
Alzheimer Disease & Associative Disorders. 1997; 11(Suppl2) :S13–21
A global reference for human genetic variation
The 1000 Genomes Project Consortium
Nature 526, 68-74 (01 October 2015) doi:10.1038/nature15393
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Lambert JC, Ibrahim-Verbaas CA, Harold D et al. 
Nature Genetics 2013; 45(12):1452-8